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Research
The interests of our lab are generally centered around the study of learning and memory, decision making, and executive control. Much of work is focused on basic cognitive and neural mechanisms, but we are also heavily involved in translational research into the mechanisms of neuropsychiatric disorders.
Funded projects
The Cognitive Atlas
The Cognitive Atlas project aims to develop an ontology for cognitive processes through social collaborative knowledge building.
Automaticity, Habit, and Cognitive Control (funded by a James S. McDonnell Foundation 21st Century Science Award)
This project is examining the relation between habitual behaviors and executive control in normal populations. In particular, we are examining how the ability to control behavior changes as a person becomes highly skilled in a task.
The neural basis of risky decision making (funded by the National Science Foundation)
This project, which is collaborative with Craig Fox in the UCLA Anderson School of Management, is examining the neural systems involved in economic decision-making under conditions of risk and uncertainty.
Predictive analyses of training-related plasticity using fMRI and pattern classification techniques (funded by the Office of Naval Research)
This project using machine learning techniques to examine the utility of fMRI in predicting the nature of skilled behavior.
Longitudinal assessment of frontostriatal activation in patients with presymptomatic Huntington's disease (funded by the High-Q Foundation).
This project is examining whether fMRI can be used as a biomarker for progression of Huntington's disease in presymptomatic carriers of the Huntington's disease gene.
Center grants
Consortium for Neuropsychiatric Phenomics (funded by NIH, PI: R. Bilder)
This Roadmap Interdisciplinary Research Consortium is leveraging the new discipline of phenomics to understand neuropsychiatric disorders at multiple levels, from genes to neural systems to cognitive processes to psychiatric syndromes.
CIDAR: Translational Research to Enhance Cognitive Control (funded by NIMH 1P50MH077248 J.McCracken, Center PI)
This
center is dedicated to translational research focused on interventions
(both pharmacological and behavioral) to improve cognitive control in
children with neuropsychiatric disorders.
Methamphetamine Abuse, Inhibitory Control: Implications for Treatment (funded by NIDA P20DA022539, E. London, PI)
This exploratory center is investigating novel mechanisms for enhancing cognitive
control as a therapeutic approach in methamphetamine abuse.
Joint projects
We are also involved in several projects that are funded through grants to other principal investigators at UCLA.
Cortico-striatal dysfunction and vulnerability to schizophrenia (funded by NIH 1R24MH072697, PI: R. Asarnow)
This project is investigating the nature of striatal dysfunction in relatives of schizophrenics and in high-risk prodromal populations, in order to better understand the role of striatal function in schizophrenia.
Neural systems, inhibitory control, and methamphetamine dependence (funded by NIH 1RO1DA020726, PI: E. London)
This project is investigating the neural systems involved in deficient inhibitory control in methamphetamine abusers, and examining whether modafinil has beneficial effects in ameliorating these deficits.
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